They also recommend developing strategies to help patients return to activity gradually; conserve their energy; eat healthy foods; stay hydrated; and follow, if necessary, a regimen of medications and herbal and vitamin supplements. https://doi.org/10.1007/s40122-023-00486-1, DOI: https://doi.org/10.1007/s40122-023-00486-1. https://doi.org/10.1016/j.bja.2020.05.021. The high expression of angiotensin-converting enzyme-2 (ACE2) receptors within nervous system cells such as neurons and microglia of the spinal cord could explain the neuro-invasive potential of the COVID-19-associated neuropathic symptoms [86]. Chronic pain during and post-COVID-19 pandemic is an important health issue due to the significant impacts of pain on the patients, health care systems, and society as well. Nat Rev Mol Cell Biol. Cardiovascular health: Insomnia linked to greater risk of heart attack. For example, we want to ensure that they dont have inflammation of their heart, that their lungs are working well, and that they have no heart rhythm problems., If patients clear those tests, a difficult path sometimes lies before them. Prevalence and risk factors associated with mental health symptoms among anesthetists in Saudi Arabia during the COVID-19 pandemic. The prevalence of myalgia was higher in hospitalized patients (22.7%) compared to in non-hospitalized patients (16.8%). Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review. The vast majority of patients with persistent musculoskeletal pain after SARS-CoV-2 will have no joint swelling or inflammation and the physical examination will typically be unrevealing. About half of the adults treated at hospitals for COVID-19 have experienced lingering symptoms, financial difficulties, or physical limitations months after being discharged, according to a National Institutes of Health - supported study published in JAMA Network Open. Telemedicine plays an important role in consulting physicians and health care providers without unnecessary exposure [9, 16]. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Lowenstein CJ, Solomon SD. Can exercise prolong life for aging people with HIV? [Article in Spanish] . Treatment-refractory headache in the setting of COVID-19 pneumonia: migraine or meningoencephalitis? The following related keywords were used for the search (COVID-19, coronavirus and SARS-CoV-2, post-COVID pain, post-COVID pain syndromes, post-COVID headache, post-COVID chronic pain post-COVID neuropathic pain and post-COVID musculoskeletal pain). Google Scholar. El-Tallawy, S.N., Perglozzi, J.V., Ahmed, R.S. Article There is an association between chronic pain comorbidities and psychiatric disorders with fibromyalgia [113]. 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study. Considering the potential for an increase in chronic pain after the COVID-19 pandemic. 2020;2(12):250910. The use of telemedicine may be declining after the pandemic, with a return to normal life and improved access to care even for patients living in areas remote from the clinic. 2020;395:14178. 2020;2(8):12003. COVID in patients with underlying heart disease is a known risk factor for complications, Altman said. You can upload files and images in the next step. Angina develops when the heart muscle does not receive enough oxygen in the blood. Always consult a specialist or your own doctor for more information. People with COVID-19 can experience what's called substernal chest pain, or aching under their breastbone. Why do I feel weak, dizzy, numbness in face and jaws, and nasal congestion post-COVID? If the heart muscle tissue develops inflammation, doctors refer to it as myocarditis. These have the potential to result in persistent neuropathic and musculoskeletal pain after ICU discharge. For decades, mobile methadone clinics have used vans or other vehicles to bring methadone maintenance programs into the community. These cookies will be stored in your browser only with your consent. Effective treatment of post-COVID headache should take into consideration the type of headache (migrainous vs. tension-type-like), comorbidities, and if present, additional post-COVID-19 symptoms such as insomnia, mood disorders, and cognitive difficulties [15, 74]. 2022;7:31. https://doi.org/10.1038/s41541-022-00453-5. No funding or sponsorship was received for this study or publication of this article. 2021. Fernndez-de-las-Peas C, Navarro-Santana M, Plaza-Manzano G, Palacios-Cea, Arendt-Nielsen L. Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis. PubMed https://doi.org/10.1080/00207411.2022.2035905. China JAMA Neurol. It often causes peripheral or central neurological complications, either through direct invasion of the nervous system or through immune reactions (35, 36). Muller JE, Nathan DG. 2022;377. doi:10.1136/bmj-2021-069676. Why do I feel weak, dizzy, numbness in face and jaws, and nasal congestion post-COVID? Headache may be manifested with a migraine or more frequently, with a tension-type-like phenotype. Post-COVID-19 pain is prevalent and can develop into more challenging and persistent pain. Can adults with COVID-19 develop costochondritis? They are more susceptible to morbidity and mortality from COVID-19. Pain Report. To focus on the strategies to overcome the limitations in healthcare delivery and providing the appropriate management for chronic pain patients. Risk factors in (hospitalized) COVID-19 patients: risk factors for the development of persistent and chronic pain post-COVID-19 in hospitalized patients and their mechanisms have been identified. Simply put, Trying to avoid infection overall is preferable, Altman said. Increased demand on the health care systems, health care workers, and facilities. Not all of these will be relevant in the treatment of COVID-19-induced angina. 2022;51(4):44869. Most people who develop COVID-19 fully recover, but current evidence suggests approximately 10%-20% of people experience a variety of mid- and long-term effects after they recover from their initial illness. The inflammation may be caused by repeated coughing from the infection. However, researchers are still looking at long covid and finding potential remedies. 2022;26:37983. Bradykinins contribute to pro-inflammatory state and also sensitize the sensitive fibers, leading to hyperalgesia [56, 57, 61, 64]. It may be treated with NSAIDS and colchicine. Necessary cookies are absolutely essential for the website to function properly. If the SARS-CoV-2 virus affects the heart valve or muscle tissue, it can lead to heart inflammation. Musculoskeletal pain: The Pain Task Force of the (IASP), defines Chronic Primary Musculoskeletal Pain (CPMP) as chronic pain in the muscles, bones, joints, or tendons that is characterized by significant emotional distress (i.e., anxiety, anger, frustration, and depressed mood) or functional disability [9, 18]. The programs have policies and procedures to store, transport, deliver, account for, reconcile, and dispose of opioid waste and would be subject to audit. Decreased metabolic pathways: Anti-viral medications, e.g., lopinavir/ritonavir inhibiting CYP3A4, and this may inhibit the metabolic pathway of some opioids (e.g., oxycodone) resulting in increased plasma levels, with possible increasing the risk of overdose and respiratory depression [126, 128, 129]. All rights reserved. Symptoms may be new-onset following initial recovery from an acute COVID-19 episode or persist from the initial illness. 2021;1:3644. J Intern Med. People stopped exercising, getting fresh air and sunshine, and socializing, which led to anxiety, depression, isolation, and fearfulness. Compared to traditional viral myocarditis, the tachycardia condition is very different. Safety and efficacy of low dose naltrexone in a long COVID cohort; an interventional pre-post study. COVID-19 seems to have the potential to cause pain in a variety of ways, including damage to peripheral nerves causing neuropathy-like symptoms, by affecting pain pathways inside the brain, and by weakening or disrupting the activity of the musculoskeletal system. 2021;4(10):e2128568. Blogs are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. 2002;6:5402. As the research on COVID continues, well get a better understanding of the best ways to treat the different complexities and variations of pain problems. Acute pain associated with viral infection is common in the early stages of acute COVID-19. Symptoms and conditions that can affect children after COVID-19. Accessed: May 24, 2021: https://www.opensocietyfoundations.org/publications/lowering-threshold. It affects between 14 and 60% of patients during the acute COVID-19 phase [70, 71]. Patients with chronic pain infected with COVID-19 are at higher risk for exacerbation of their symptoms, and this is attributed to many factors including social threats, discontinuation of therapy, reduced access to treatments, or associated mental health problems and concerns about health outcomes [25, 30, 31]. Another proposed mechanism was the direct viral entry of cells of the musculoskeletal and nervous systems mediated by angiotensin-converting enzyme 2 (ACE2) receptor [42, 61, 62]. Also, the Medical Council of India along with National Institution for Transforming India (NITI Aayog) released Telemedicine Practice Guidelines enabling registered medical practitioners to provide healthcare using telemedicine [22]. Getting medical support for chest pain is vital because it can indicate a serious health problem. He served as a writer and editor for the Marketing and Communications team at University of Colorado Hospital and UCHealth from 2007 to 2017. 2021. https://doi.org/10.1093/ehjcr/ytab105. 2022;58:1500. https://doi.org/10.3390/medicina58101500. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) such as Advil or Motrin (ibuprofen), Aleve (naproxen), Mobic (meloxicam), or Colcrys (colchicine) can be initiated to reduce pain and preserve quality of life. Pain. The exact mechanisms causing post-COVID pain remain unclear. Mild cases of chest pain may resolve following recovery from acute COVID-19 and not requiring further treatment. Haddarah: revision of the final draft. Altman noted that the heart has receptors ACE2 (angiotensin-converting enzyme 2) to which the SARS-CoV-2 protein binds. https://doi.org/10.1097/CCM.0000000000003347. Program-directed training for self-management, rehabilitation, and physical therapy should be created and available via video tutorials and applications for smartphones [116,117,118]. Rania S. Ahmed: searching, study screening, editing. https://doi.org/10.1002/jmv.25757. Soares FHC, Kubota GT, Fernandes AM, et al. Around 69% of general practitioners would refer patients for radiography at first presentation, despite routine use discouraged due to a poor relationship of imaging findings with symptoms. International pain associations have warned physicians in guidelines published during the pandemic that patients may be more susceptible to COVID-19 and other secondary infections while using opioid analgesics [20, 127]. Angina requires a range of possible treatments depending on its severity. COVID-19 Chest Pain. (2022). Because COVID-19 most often affects the lungs, lingering respiratory symptoms are not uncommon. Pain Phys. Symptoms that may occur alongside this pain include: Pericarditis causes pleuritic pain that feels better when a person sits up and leans forward. https://doi.org/10.1016/j.bja.2019.03.025. The study results suggested that non-invasive stimulation of the auricular branch of the vagus nerve is a possible therapeutic modality for treating long COVID with at least a third of the patients showing improvement, although it is possible that the positive result was simply a placebo response to treatment in the absence of a control group for comparison [134]. An exercise-based rehabilitation program showed change of maximum oxygen uptake [56], while hyperbaric oxygen treatment patients will be subjected to 100% oxygen by mask for 90min with 5-min air. 2021;10:181209. The mobile narcotic program uses technology, such as smartphone apps or online resources, and may allow mobile patients to benefit from counseling as well. I must mention that a few years ago, I probably had a stroke, but I never consulted or checked it with doctors. A significant proportion of patients with COVID-19 experienced long-term and persistent symptoms. Trajectory of long COVID symptoms after COVID-19 vaccination: community based cohort study. 2021;12: 624154. https://doi.org/10.3389/fphys.2021.624154. Results showed improvements of fatigue, well-being, and quality of life [133]. In the following weeks, something was moving in my head. Ryabkova VA, Churilov LP, Shoenfeld Y. Neuroimmunology: what role for autoimmunity, neuroinflammation, and small fiber neuropathy in fibromyalgia, chronic fatigue syndrome, and adverse events after human papillomavirus vaccination? Finnerup NB, Attal N, Haroutounian S, Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanp M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Pain Med. Crit Care Med. All rights reserved. Salah N. El-Tallawy (Corresponding Author): concept and design, writing, searching, supervision for all steps. She is being treated for chest pain, fatigue, and some of her other symptoms both through the specialist long Covid clinic . This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. Case studies have shown that colchicine may be an effective treatment for costochondritis, especially when conventional therapies have failed. The mainstay of treatment is represented by gabapentoids, antidepressants, tramadol, and topical agents (lidocaine plasters, capsaicin patches or botulinum toxin). Accordingly, the main objectives of this review are: To give a brief report about the challenges facing the chronic pain management during post-COVID-19. The main causes of chest pain in Post Covid Recovery patients are: 1) Post respiratory problems like ARDS and interstitial pneumonia specially after a prolonged critical illness period. However, more research is needed to understand the actual problem of post-COVID pain, the possible pathophysiological mechanisms, and the target-directed prevention and management of post-COVID chronic pain. COVID-19 may exacerbate preexisting pain or be associated with the appearance of new pain. Google Scholar. http://creativecommons.org/licenses/by-ncnd/4.0/. COVID-19 and pain: what we know so far. Researchers adjusted for pre-existing conditions and found that after one year, those who had COVID-19 were 63% more likely to have some kind of cardiovascular issue, resulting in about 45 additional cases per 1,000 people. https://doi.org/10.1007/s40122-020-00190-4. It has been reported in 2162.5% of the patients according to different meta-analysis studies [67, 105, 106]. 2020;92(6):57783. Abdullah M. Kaki: revision of final draft, editing. It was found that almost 25% of previously hospitalized COVID-19 survivors with de novo post-COVID pain reported a neuropathic pain component [30, 31]. Fiala K, Martens J, Abd-Elsayed A. Post-COVID Pain Syndromes. 2010;66:97785. Read our, Complications of Costochondritis and COVID-19. J Autoimmun. Some of these are people in their 20s and 30s who were perfectly healthy before COVID mountain bikers and hikers who are now completely debilitated. https://doi.org/10.1097/PR9.0000000000000884. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Clin Med. More recently, he has reported for and contributed stories to the University of Colorado School of Medicine, the Colorado School of Public Health and the Colorado Bioscience Association. Patients can help themselves with low-intensity, recumbent exercise, gradually increased over time. Triptans have been considered as acute therapeutic options [72, 74]. JAMA Neurol. The prevalence of post-COVID musculoskeletal pain increased at 60days, but decreased later on after 180days [42, 67, 92]. He is the medical director and co-founder of the renowned Bay Area Pain and Wellness Center and the author of Conquer Your Chronic Pain: A Life-Changing Drug-Free Approach for Relief, Recovery, and Restoration andTake Charge of Your Chronic Pain: The Latest Research, Cutting-Edge Tools, and Alternative Treatments for Feeling Better. Its even rarer to see myocarditis in patients post-COVID, although it occurs occasionally. Can diet help improve depression symptoms? It ranks among the ten most prevalent diseases worldwide and years lost to disability. A higher prevalence of musculoskeletal pain was also reported in non-hospitalized patients than hospitalized patients [61, 93]. Pleuritic COVID-19 pain due to pericarditis may start to feel better when a person sits up and leans forward and may briefly feel better while taking shallow breaths. fatigue. https://doi.org/10.1086/376907. Glucocorticoid injections for pain procedures and musculoskeletal pain may interfere with the potency and efficiency of COVID-19 vaccines. Quitting smoking may lead to various unpleasant withdrawal symptoms, such as chest pain. Myalgia was commonly experienced at the acute phase and persists as a component of long COVID in some patients [61, 109]. It may be due to inflammation of the cartilage that attaches the ribs to the breastbone (sternum). COVID-19 often causes peripheral or central neurological complications and induces post-viral immune syndrome. N Engl J Med. To describe the prevalence, risk factors, and possible mechanisms of chronic pain conditions associated with long COVID-19. Niehaus and his colleagues maintain that treating fatigue in long COVID requires addressing problems like inadequate sleep and nutrition; infectious and autoimmune diseases; and heart, lung and nerve disorders. 2019;20:5164. Wadehra S. COVID long haulers and the new chronic pain profile. In hospitalized patients, the five most prevalent symptoms reported were fatigue (28.4%), pain/discomfort (27.9%), impaired sleep (23.5%), breathlessness (22.6%), and impaired usual activity (22.3%) [7]. Angina causes pain in the chest that can feel like pressure or tightness. It does appear like post-COVID myalgia or post-COVID fatigue syndrome. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for pleuritic chest pain. https://doi.org/10.1001/jamanetworkopen.2021.28568. Prakash S, Shah ND. Therefore, it is vital to seek a. 2016;44:198895. Patient weakness may contribute to rapid deconditioning and joint-related pain, which may help to explain why chronic shoulder pain has been particularly prevalent in patients who were seen in the ICU for coronavirus treatment [53, 54]. The situation is worsened due to additional procedural pain, lack of resources, and overstretched health care services making low priority for symptomatic management of pain [21], while long COVID-19 is associated with an increased number of chronic pain patients either due to worsening of preexisting chronic pain or appearance of new painful conditions. J Clin Med. New methods for drug prescription, refill of medications and delivery of controlled medications such as mobile opioid clinics. Telemedicine does not replace clinical practice and the need of face-to-face consultations and patients examination, especially for new patients, rapid changes of the patients condition, or those with associated multiple comorbidities [22, 60, 117]. weakness. Pain Report. Pain procedures for high-risk patients: [9, 11, 16]. Agri. Also, the dizziness and lightheadedness could be part of the dysautonomia in post-COVID patients. This article will explore the risks, complications, and treatments of COVID-induced costochondritis induced by COVID-19. These symptoms can feel worrying, especially if you already have a heart condition. This newly introduced communication technology needs comprehensive program-directed education and training for both the HCWs and the patients to develop the competences needed to engage with digital tools [116, 117]. pain and inflammation relief medications, including: sudden or severe chest pain that does not resolve. The management of chronic pain during the COVID-19 pandemic is a challenging process, especially with growing evidence that COVID-19 infection is associated with persistent myalgias, referred pain, and widespread hyperalgesia [9]. COVID-19 is considered as a current trigger in some patients. I have suffered from some weakness attacks for many months. Lancet. New daily persistent headache after SARS-CoV-2 infection: a report of two cases. The search strategy was restricted to articles that were published between January 2020 and January 2023. Costochondritis, a painful chest pain due to swelling of the cartilage that attaches to the sternum, is a rare post-COVID symptom that some children may experience. https://doi.org/10.1097/NNR.0000000000000565. Arca KN, Starling AJ. Chronic pain conditions can be triggered by psychosocial stressors or organ-specific biological factors. It follows that she and her colleagues no longer see long haul COVID as a single entity, Altman added. Post-COVID headache was relatively higher in patients managed in an outpatient setting [45]. Myositis is muscle inflammation caused by metabolic abnormalities, which may be triggered by COVID-19 infection. If a more protracted course of COVID (over 6months) is demonstrated, the term long-COVID is used. All rights reserved. 2009;9:50917. Brachial plexopathy after prone positioning. According to the National Institute for Health and Care Excellence (NICE) guidelines, long COVID is commonly used to describe signs and symptoms that continue or develop after acute infection consistent with COVID-19 and persist longer than 4weeks. https://doi.org/10.1016/j.jpainsymman.2012.08.013. Is the ketogenic diet right for autoimmune conditions? The selected articles for inclusion were screened by two independent reviewers using the same method of evaluation. Chronic pain patients may experience additional potential risk of functional and emotional deterioration during a pandemic, which can increase the long-term health burden [19, 20]. What is the latest research on the form of cancer Jimmy Carter has? Hong SM, Park YW, Choi EJ. For neuropathic pain symptoms, gabapentoids are suitable options [9, 121]. Chest pain. 2010;11(1):5966. In angioplasty, a doctor inserts a thin tube (a catheter) into the person and inserts a tiny balloon through it. 2022;163:122031. Symptoms of COVID-19 outpatients in the United States. Weve also seen very different symptoms and presentations and learned to develop patient-specific treatment regimens.. Pain. https://doi.org/10.1016/j.heliyon.2022.e10148. https://doi.org/10.1111/joim.13091. We know from experience that coming out of an intensive care unit is often associated with lingering pain problems, as well as cognitive deficits, psychological distress, and difficulties regaining physical function with daily activities. 2021;18(9):122. Coronary micro-vascular ischemia could be the mechanism of persistent chest pain in patients that have recovered from COVID-19 [101]. 2020;142:160911. Flow chart of inclusion of studies (PRISMA, 2009) [10]. And we know that patients who spend a prolonged period of time immobilized or on a ventilator are likely to develop muscle atrophy, weakness, and neurologic problems, all of which can lead to persistent pain challenges. J Clin Med. No additional benefits for doses greater than 10mg triamcinolone or 4mg dexamethasone were observed [122, 123]. Hruschak V, Flowers KM, Azizoddin DR, Jamison RN, Edwards RR, Schreiber KI. Available from: https://www.nice.org.uk/guidance/ng188/resources/COVID19-rapid-guideline-managing-thelongterm-effects-of-COVID19-pdf-51035515742. (2010). Article https://www.england.nhs.uk/coronavirus/post-COVID-syndrome-long-COVID/, Headache Classification Committee of the International Headache Society. 2021;398:747. Myalgia as a symptom at hospital admission by SARS-CoV-2 infection is associated to persistent musculoskeletal pain as long-term post-COVID sequelae: a case-control study. Some of the pain related to COVID-19 is related to hospitalization and treatment -- and these are types of pain were somewhat familiar with. SN Compr Clin Med. By continuing to use this site you are giving us your consent. Another study compared two groups of patients, one group admitted to the hospital due to COVID-19 infection and the other group admitted due to other causes. El-Tallawy SN, Nalamasu R, Salem GI, LeQuang JK, Pergolizzi JV, Christo PJ. c) Regular follow up and assessment of cardio pulmonary sequelae helps in resolution of primary cause and resolves secondary symptoms like chest pain.". COVID-19 is associated with inflammation in the lungs and other parts of the body, such as the heart, brain, and muscles. Kosek E, Cohen M, Baron R, et al. Chronic opioid therapy with high doses may induce immunosuppression. Track Latest News and Election Results Coverage Live on NDTV.com and get news updates from India and around the world. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Cohort profile: Lifelines, a three-generation. Natelson B, Blate M, Soto T. Transcutaneous vagus nerve stimulation in the treatment of long COVID chronic fatigue syndrome. Costochondritis has appeared as a common theme among patients after covid-19. A review of persistent post-COVID syndrome (PPCS). Musculoskeletal pain may occur three different ways: first, de novo musculoskeletal pain following COVID-19; second, exacerbation of preexisting musculoskeletal pain after COVID-19 infection; third, increasing musculoskeletal pain in non-infected individuals as a result of COVID-19-associated factors, e.g., lockdown, isolation, unreachable medical services [94]. Corticosteroids reduce the bodys immune response, while IVIG, which a doctor administers directly into the veins, reduces inflammation and controls the immune response. Yes. Stable opioid-tolerant patients have permitted opioid prescriptions via telemedicine to reduce the risk of withdrawal [11, 16]. But if you have any persistent problems like chest pain, shortness of breath, or feeling faint, those need to be checked out., Get the most popular stories delivered to your inbox monthly, COVID-19 can exacerbate underlying heart conditions, but long COVID symptoms like chest pain and shortness of breath also affect young, previously healthy people. Altman recommends staying active and exercising but within boundaries. A total of 194 studies including 735,006 participants worldwide were included in the analysis. J Pain Symptom Manage. Beyond that, other side effects of the vaccine for both men and women may include: redness or. It may be noticeable during or after COVID-19. The potential contribution of psychosocial factors and mental health problems [25, 65]. Pierce JD, Shen Q, Cintron SA, Hiebert JP. Pain Management in the Post-COVID EraAn Update: A Narrative Review, https://doi.org/10.1007/s40122-023-00486-1, Pain Management During the COVID-19 Pandemic, Pain as clinical manifestations of COVID-19 infection and its management in the pandemic era: a literature review, People living with HIV and the emerging field of chronic painwhat is known about epidemiology, etiology, and management, Neuropathic Pain Associated with COVID-19: a Systematic Review of Case Reports, Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review, Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project), Risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population: a systematic review and meta-analysis, Clinical presentations of pain in patients with COVID-19 infection, https://www.who.int/publications/m/item/weekly-epidemiological-update-on-COVID-19---4-january-2023, https://doi.org/10.1016/S0140-6736(20)31379-9, https://doi.org/10.1016/S1473-3099(21)00043-8, https://www.who.int/data/gho/publications/world-health-statistics, https://doi.org/10.1016/j.eclinm.2022.101762, https://doi.org/10.1007/s40122-020-00190-4, https://doi.org/10.1016/j.jclinepi.2009.06.005, https://www.nice.org.uk/guidance/ng188/resources/COVID19-rapid-guideline-managing-thelongterm-effects-of-COVID19-pdf-51035515742, https://www.who.int/standards/classifications/classification-of-diseases/emergency-use-icd-codes-for-COVID-19-disease-outbreak, https://www.england.nhs.uk/coronavirus/post-COVID-syndrome-long-COVID/, https://doi.org/10.1016/j.bpa.2020.07.001, https://doi.org/10.23736/S0375-9393.20.15029-6, https://iris.paho.org/bitstream/handle/10665.2/28414/9789275119037_eng.pdf?sequence=6&isllowed=y, https://doi.org/10.1016/j.bja.2020.05.021, https://doi.org/10.1080/00207411.2022.2035905, https://doi.org/10.1186/s10194-022-01450-8, https://doi.org/10.1093/pm/pnaa143.pnaa143, https://doi.org/10.1016/j.bja.2019.03.025, https://doi.org/10.1016/j.ejim.2021.06.009, https://doi.org/10.1097/j.pain.0000000000002564, https://doi.org/10.1016/j.bja.2020.06.003, https://doi.org/10.1007/s40122-021-00235-2, https://doi.org/10.1097/CCM.0000000000003347, https://doi.org/10.1007/s12016-021-08848-3, https://doi.org/10.1097/NNR.0000000000000565, https://doi.org/10.1038/s41591-021-01283-z, https://doi.org/10.1007/s10067-021-05942-x, https://doi.org/10.1038/s41580-021-00418-x, https://doi.org/10.1097/PR9.0000000000000885, https://doi.org/10.1097/j.pain.0000000000002306, https://doi.org/10.1001/jamanetworkopen.2021.28568, https://mhnpc.com/2021/05/18/COVID-triggers-increased-pain-management-needs/, https://doi.org/10.1038/s41541-022-00453-5, https://doi.org/10.1097/PR9.0000000000000884, http://creativecommons.org/licenses/by-ncnd/4.0/, https://doi.org/10.1016/j.heliyon.2022.e10148, https://doi.org/10.1007/s11916-022-01038-6, https://doi.org/10.1371/journal.pmed.1003773, https://doi.org/10.3389/fphys.2021.624154, https://doi.org/10.1016/j.jfma.2020.04.024, https://doi.org/10.3390/healthcare10122349, https://www.opensocietyfoundations.org/publications/lowering-threshold, https://www.uptodate.com/contents/COVID-19-evaluation-and-management-of-adults-with-persistent-symptoms-following-acute-illness-long-COVID#disclaimerContent, https://doi.org/10.1007/s00228-010-0879-1, https://doi.org/10.1016/j.jpainsymman.2012.08.013, https://doi.org/10.1038/s41598-022-24053-4, https://doi.org/10.1016/j.bbih.2022.100485, https://doi.org/10.1101/2022.11.08.22281807v1, http://creativecommons.org/licenses/by-nc/4.0/.
Equestrian Stockholm Saddle Pads, Articles S